Jouw functie

The Netherlands Cancer Institute (NKI) in Amsterdam is a Comprehensive Cancer Centre combining a hospital and research laboratories in a single independent organization. The groups of Titia Sixma and Anastassis Perrakis work in the Division of Biochemistry focusing on Integrative Structural Biology. We offer an outstanding scientific environment with plenty of opportunities for learning and development, and we are a social and collaborative group.

We are looking for enthusiastic, motivated PhD students and Post-Docs to join the Division of Biochemistry in the groups of Tassos Perrakis and Titia Sixma. If you have a keen interest in the general field of integrative structural cell biology, and previous experience in cryo-EM, X-ray crystallography, cell biology, biochemistry, or biophysics … well, read on!

The project in the laboratory of Titia Sixma is in the area of DNA repair.

The projects in the laboratory of Anastassis (Tassos) Perrakis are in the general field of controlling the progress of cell division and microtubule interacting proteins, in lysolipids signaling focusing on Autotaxin and its interactions, and together with Robbie Joosten in PDB-REDO.

The two groups share a common research infrastructure in the Department of Biochemistry, and have an interest in structural studies coupled to functional analysis. Facilities include the ability to produce and purify proteins in bacterial, insect, and mammalian cells, and a well-equipped macromolecular biophysics laboratory that are sites in the Instruct Centre NL. Equipment for structural analysis is spearheaded by a brand-new cryo-EM (Jeol F2 200kV with a K2 detector) and high-throughput crystallisation robotics; these local facilities are coupled with regular access to Krios cryo-EM at NeCEN and to the ESRF, SLS and DLS synchrotrons, and access possibilities for NMR experiments. Dedicated computing facilities include privileged access to both CPU and GPU clusters. Both groups participate in various European and National collaborative projects and are members of the Oncode Institute ().

Jouw profiel

We are looking flexibly for either highly motivated PhD students (strong master-level placements in reputable laboratories and familiarity with some of the methods we outline would be strong plus) or post-docs (experience in cryo-EM would be highly desirable for most positions; candidates with a strong background and track record in X-ray crystallography, protein purification, cell biology, would be taken seriously under considerations depending on the project). For the PDB-REDO project a background in bioinformatics and some experience in computer programming would be necessary; feel free to also make informal inquiries.
  • An MSc degree in a related discipline and practical experience in a reputable laboratory for PhD students;
  • A PhD degree in a related discipline for post-doctoral scientists;
  • Excellent communication and collaboration skills because you will be working in a multidisciplinary team;
  • Fluent in spoken and written English.

Jouw ontwikkelingsmogelijkheden en arbeidsvoorwaarden

Approximately 550 people work in the research laboratories. Research discussions, lectures and seminars in English and a large number of Dutch and non-Dutch postdocs, students and staff members contribute to the stimulating and international atmosphere of the Institute. We offer an inspiring and interactive research environment, state-of-the-art facilities, training, a competitive salary (including possibilities for tax-reduction for non-Dutch candidates) and housing facilities in the vicinity of the Institute. The Institute is located close to the city centre of Amsterdam and the international Schiphol airport.

The appointment will initially be for 4 years PHD-students and 2-4 years (post-docs). PHD-Position:
For the PHD-position the gross salary per month will range from € 2.798,- to € 3.446, according to the standard PhD scales.

Post-doc position:
For the Post-doc position the gross salary per month ranges from €3.664- to € 4.111 according to the postdoc scales and depends on previous experience. The terms of employment will be in accordance with the CAO Ziekenhuizen (Collective Labour Agreement for Hospitals).

Contact informatie

For further information please consult our website: or contact and/or

Please send in your resume together with a short and a clear letter stating your interest in the type of position (PhD/Post-doc) and outlining the specific scientific interest in our projects (application without specific expression of scientific interest based on our work as you can see it from the short description above and from our recent publication record, will not be evaluated favourably). Please send application via the “apply now” button; in case this does not work you can send it to:

Acquisition for this vacancy is not appreciated.